放射線に対する免疫機能の応答(3)
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| Fig15 | The number and incidence
of mefastases in lung and lymph nodes of mediastinum and axilla 50
days after intramuscular (leg) tumor implantation in rats,and the
number of tumor infiltrating lymphocytes 21 days after implantation.
Total body or localized tumor irradiation ,with 0.2 Gy was given 14
days after implantation 5×10
allogenic hepatoma cell. Hashimoto et al. Radiation Res.151:717-729(1999).
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図15 担癌ラットでの全身照射による転移の抑制
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全身照射ではコントロールや局部照射の場合に比べ、肺、縦隔、腋窩リンパ節への転移の70％以上が抑制され、腫瘍組織へのリンパ球の浸潤は900％以上増加した。
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| Fig16 | Dose-response analysis
of splenin T cell proliferative response 3-5d after the last radiation
exposure of immunologically normal,long-lived C57B1/6J ＋/＋ mice.Results
are expressed as the mean percent increase in  H-thymidine
uptake relative to 0 Gycontrol group as 100%. The vertical bars =
1SEM. Makinodan and James(1990); adapted from James and Makinodan(1988). |
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図16 複数回のTBIによるマウス脾臓T細胞増殖の亢進
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低線量放射線5日/週で4週間合計10、20、80radの照射をうけたマウスでは非照射グループに比べて115、140、160％の増殖がみられた。
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| Fig17 | Eight month old, mammary tumor-susceptible, female C3H/He mice were first adjusted in a stepwise manner to chronically restricted diet (calorically 70% of ad libitum diet)(CRD) over a period of 3 weeks. The mice were maintained on CRD until completion of the study. After their diet was adjusted, the mice were exposed to TBI (0.04Gy, 3 alternating days/week, 4 weeks) and were observed for 35 weeks. Tumor regression of the CRD＋TBI group was very rapid and large numbers of CD8＋T cells were found infiltrating the regressing tumors, which were not seen in mice of the untreated control, LDR and CRD groups. Adapted from Makinodan (1992). |
| 図17 | 低線量放射線照射と制限食による乳がんの抑制と除去作用 |
8週齢の乳がん自然発症マウスに3週間の制限食と4週間48radの照射を与え、35週観察した。自由食マウスの73％、制限食マウスの27％そして制限食＋照射マウスの16％に乳がんが発生した。また腫瘍の縮小はそれぞれ4、20、80％に見られた。
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